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Hyperthermic intra-peritoneal chemotherapy and anticancer immune response
Barbara Zunino1, Jean-Ehrland Ricci1
1Inserm, U1065; Centre Méditerranéen de Médecine Moléculaire (C3M); équipe "contrôle métabolique des morts cellulaires"; Nice, France; Université de Nice-Sophia-Antipolis; Faculté de Médecine; Nice, France; Centre Hospitalier Universitaire de Nice; Département d'Anesthésie Réanimation; Nice, France.
Heated intra-peritoneal chemotherapy (HIPEC) combined with surgery improves survival for peritoneal carcinomatosis. This treatment enhances anticancer immune responses, contributing to its protective effects.
Area of Science:
- Oncology
- Immunology
- Surgical Oncology
Background:
- Peritoneal carcinomatosis (PC) is advanced abdominal cancer with a poor prognosis.
- Current treatments offer limited survival benefits for PC patients.
Purpose of the Study:
- To investigate the mechanisms behind the efficacy of heated intra-peritoneal chemotherapy (HIPEC) in treating peritoneal carcinomatosis.
- To determine if HIPEC induces an anticancer immune response.
Main Methods:
- Review of existing literature on HIPEC and peritoneal carcinomatosis.
- Analysis of immune response markers in patients treated with HIPEC.
Main Results:
- Heated intra-peritoneal chemotherapy (HIPEC) significantly improves patient survival in peritoneal carcinomatosis.
- HIPEC treatment was associated with the induction of an effective anticancer immune response.
Conclusions:
- The protective effects of HIPEC in peritoneal carcinomatosis are partially mediated by the immune system.
- Targeting the immune response could be a future strategy to enhance HIPEC efficacy.
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