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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
1Hargadon Laboratory, Department of Biology, Hampden-Sydney College , Hampden-Sydney, VA, USA.
Oncoimmunology
|March 5, 2016
Abstract:
We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth.
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