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Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

Jennifer C Price1, Eric C Seaberg, John P Phair

  • 1*Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, CA; †Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; ‡Division of Infectious Diseases, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL; §Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA; ‖Division of Infectious Diseases, Department of Medicine, Ohio State University, Columbus, OH; and ¶Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD.

Journal of Acquired Immune Deficiency Syndromes (1999)
|March 6, 2016
PubMed

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

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