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Fractionated elution using the TEKCIS technetium-99m generator.

Jonathan Vigne1, Rémy De Mil, Damien Peyronnet

  • 1Departments of aNuclear Medicine bPharmacy cUMR 1086 INSERM-UCBN, CHU de Caen dEA 4650 University of Caen-Basse Normandy, Caen F-14000, France.

Nuclear Medicine Communications
|March 6, 2016
PubMed
Summary

Fractionated elution of technetium-99m (Tc) from the TEKCIS generator provides high radioactive concentrations for radiopharmacy. This method optimizes elution timing for procedures requiring maximum Tc activity, ensuring reliable yields.

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Area of Science:

  • Nuclear medicine
  • Radiopharmacy
  • Medical physics

Background:

  • The TEKCIS technetium-99m (Tc) generator supports dry column shipment and automated production.
  • Certain radiopharmacy procedures necessitate a high concentration of Tc.
  • Fractionated elution is a technique to achieve higher Tc concentrations, particularly as generators approach expiration.

Purpose of the Study:

  • To evaluate the elution kinetics of the TEKCIS generator.
  • To identify optimal fractionated elution times for maximizing Tc radioactive concentration in clinical applications.

Main Methods:

  • Duplicate elutions were performed at various time points to measure eluate volume and activity.
  • A logarithmic equation (v=1.8335ln(t)-2.5965) was derived to correlate eluate volume with elution time.
  • Fractionated elutions of 15 and 20 seconds were tested for repeatability on generators calibrated at 6 or 8 GBq.

Main Results:

  • A complete 5 mL eluate was collected in 60 seconds.
  • Fractionated elutions of 15 and 20 seconds yielded average volumes of 2.74–3.27 mL.
  • Average elution yields for fractionated elutions were approximately 90% (15s) and 100% (20s).

Conclusions:

  • A simple and dependable method for fractionated elution with the TEKCIS generator has been established.
  • This technique allows for the reliable attainment of high Tc concentrations required for specific radiopharmacy procedures.