Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

4.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
4.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
Reticular Dermis01:15

Reticular Dermis

5.4K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
5.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.8K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.8K
Papillary Dermis01:11

Papillary Dermis

6.7K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scanning Acoustic Microscopy as a Novel Quantitative Tool for Assessing Dermal Sclerosis in Systemic Sclerosis: A Case Report.

Case reports in dermatology·2026
Same author

Possible involvement of IL-31 in pruriginosa-type recessive dystrophic epidermolysis bullosa: a nemolizumab-responsive case.

Clinical and experimental dermatology·2026
Same author

A Case of Areolar Sebaceous Hyperplasia Coexisting With an Epidermoid Cyst and Soft Fibroma.

The Journal of dermatology·2026
Same author

Ashy dermatosis-like hyperpigmentation limited to the arms associated with osimertinib therapy.

Clinical and experimental dermatology·2026
Same author

Methylprednisolone-induced immune thrombocytopenia in a patient with severe bullous pemphigoid.

European journal of dermatology : EJD·2026
Same author

Dabrafenib-induced panniculitis with interface dermatitis in a patient with thyroid carcinoma.

European journal of dermatology : EJD·2026

Related Experiment Video

Updated: Mar 24, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Erythrokeratodermia variabilis et progressiva.

Akemi Ishida-Yamamoto1

  • 1Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.

The Journal of Dermatology
|March 7, 2016
PubMed
Summary
This summary is machine-generated.

Erythrokeratodermia variabilis et progressiva (EKVP) is a rare genetic skin disorder. Mutations in connexin genes cause this condition, leading to hyperkeratotic plaques and skin redness, with potential palmoplantar keratoderma.

Keywords:
connexin 30.3connexin 31connexin 43connexinsgap junctions

More Related Videos

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

17.6K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

827

Related Experiment Videos

Last Updated: Mar 24, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

17.6K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

827

Area of Science:

  • Dermatology
  • Genetics
  • Cell Biology

Background:

  • Erythrokeratodermia variabilis et progressiva (EKVP) is a rare inherited skin disorder.
  • It presents with fixed hyperkeratotic plaques and transient erythematous patches.
  • EKVP typically follows autosomal dominant inheritance.

Purpose of the Study:

  • To summarize the genetic basis of EKVP.
  • To outline current treatment strategies.
  • To discuss potential future therapeutic approaches.

Main Methods:

  • Review of genetic mutations associated with EKVP.
  • Analysis of clinical presentation and inheritance patterns.
  • Evaluation of current and emerging treatment options.

Main Results:

  • Causal mutations identified in GJB3, GJB4, and GJA1 genes, encoding connexins.
  • Approximately 50% of patients develop palmoplantar keratoderma.
  • Connexins are key components of gap junctions in the skin.

Conclusions:

  • EKVP is linked to connexin gene mutations affecting intercellular communication.
  • Current treatments include topical agents and systemic retinoids.
  • Future therapies may target connexin hemichannels and gap junctions for improved management.