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Updated: Mar 24, 2026
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
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dbPEC: a comprehensive literature-based database for preeclampsia related genes and phenotypes
Alper Uzun1, Elizabeth W Triche2, Jessica Schuster3
1Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA Department of Pediatrics, Brown Alpert Medical School, Providence, RI, USA auzun@wihri.org.
Summary
A new database, dbPEC, compiles clinical features, genes, and literature for preeclampsia research. This resource aids in analyzing high-throughput data and understanding preeclampsia
Area of Science:
- Obstetrics and Gynecology
- Genetics
- Bioinformatics
Background:
- Preeclampsia is a leading global cause of maternal and fetal mortality.
- Existing research on preeclampsia is fragmented across various sources.
- A centralized, curated resource is needed to consolidate knowledge.
Purpose of the Study:
- To develop a comprehensive database (dbPEC) for preeclampsia research.
- To integrate clinical features, associated genes, and scientific literature.
- To provide a resource for analyzing high-throughput genomic data.
Main Methods:
- Utilized semantic data mining to extract preeclampsia-related articles.
- Performed manual curation of scientific literature for gene and phenotype information.
- Developed a database (dbPEC) to store and organize retrieved data.
Main Results:
- The dbPEC database includes clinical features, concurrent conditions, genes, and literature.
- Gene sets associated with severity, concurrent conditions, and tissue sources are incorporated.
- The database is publicly accessible and supports gene set enrichment analysis.
Conclusions:
- dbPEC serves as a valuable, freely accessible resource for preeclampsia research.
- The database facilitates the analysis of high-throughput data, including genome-wide studies.
- dbPEC can advance the understanding of genetic factors and pathways in preeclampsia.
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