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Related Concept Videos

Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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[Severe crusted scabies: A "historic" case involving the death of a 52-year-old patient].

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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[Crusted scabies: A review].

G Jouret1, R Bounemeur2, A Presle3

  • 1Service de dermatologie, centre hospitalier de Troyes, 101, avenue Anatole-France, 10000 Troyes, France.

Annales De Dermatologie Et De Venereologie
|March 8, 2016
PubMed
Summary
This summary is machine-generated.

Crusted scabies, a severe mite infestation, presents significant treatment challenges. New insights into mite biology and the immune response offer promising therapeutic avenues for this contagious condition.

Keywords:
Crusted scabiesGale croûteuseGale hyperkératosiqueGale norvégienneIL-17Sarcoptes scabiei var. hominis

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Area of Science:

  • Dermatology
  • Parasitology
  • Immunology

Background:

  • Crusted scabies is a severe form of Sarcoptes scabies infestation.
  • Characterized by hyperkeratosis with high mite counts, it is highly contagious.
  • Incidence is increasing globally, posing public health challenges.

Purpose of the Study:

  • To review recent advancements in understanding crusted scabies.
  • To explore new therapeutic strategies based on novel discoveries.

Main Methods:

  • Literature review of recent research on crusted scabies.
  • Analysis of mite biology, hyperkeratosis pathophysiology, and immune responses.

Main Results:

  • Crusted scabies involves profound hyperkeratosis and high mite burden.
  • Interleukin-17 (IL-17) plays a crucial role in the pathophysiology.
  • Understanding mite biology and host response is advancing.

Conclusions:

  • Recent discoveries offer new therapeutic perspectives for crusted scabies.
  • Targeting mite biology and IL-17 pathways may improve treatment outcomes.