Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNA folding: pseudoknots, loops and bulges.

J R Wyatt, J D Puglisi, I Tinoco

    Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
    |October 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Biophysical analysis of nucleic acids.

    Current protocols in nucleic acid chemistry·2008
    Same author

    Force unfolding kinetics of RNA using optical tweezers. II. Modeling experiments.

    Biophysical journal·2007
    Same author

    Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies.

    Nature·2005
    Same author

    The effect of force on thermodynamics and kinetics: unfolding single RNA molecules.

    Biochemical Society transactions·2004
    Same author

    [A 65-year-old woman with mediastinal enlargement].

    Revista clinica espanola·2004
    Same author

    Efficacy of directly observed treatment of HIV infection: experience in AIDS welfare homes.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2004

    RNA molecules adopt specific 3D structures essential for biological function. This study details RNA structural elements, highlighting the novel pseudoknot tertiary motif.

    Area of Science:

    • Molecular Biology
    • Structural Biology
    • Biochemistry

    Background:

    • RNA molecules perform diverse biological functions.
    • The function of RNA is dictated by its three-dimensional structure.
    • RNA structure is formed through interactions between nucleotides, creating secondary and tertiary motifs.

    Purpose of the Study:

    • To describe the basic structural elements of RNA.
    • To emphasize the pseudoknot as a novel tertiary structural motif.

    Main Methods:

    • Review of existing literature on RNA structure.
    • Analysis of characteristic secondary-structure motifs.
    • Identification and description of tertiary interactions, including pseudoknots.

    Main Results:

    Related Experiment Videos

    • RNA structure is hierarchical, involving secondary motifs and tertiary interactions.
    • Tertiary interactions orient secondary structures to form functional RNAs.
    • The pseudoknot is identified as a significant tertiary motif.

    Conclusions:

    • Understanding RNA's three-dimensional structure is key to understanding its function.
    • The pseudoknot represents an important, novel tertiary structural motif in RNA.