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Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: Mar 24, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

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The geriatric mania asenapine study (GeMS).

Y Barak1, I Finkelstein2, S Pridan1

  • 1Abarbanel Mental Health Center, Affiliated with the Sackler School of Medicine, Tel-Aviv University, Bat-Yam, Israel.

Archives of Gerontology and Geriatrics
|March 9, 2016
PubMed
Summary
This summary is machine-generated.

Asenapine effectively reduced manic symptoms in older adults, with over half achieving remission. Caution is advised for elderly patients with co-existing physical conditions.

Keywords:
AsenapineElderlyMania

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Area of Science:

  • Geriatric Psychiatry
  • Pharmacology

Background:

  • Population aging is associated with an increase in psychiatric disorders among older adults.
  • There is a significant lack of research on mania in the elderly population.

Purpose of the Study:

  • To evaluate the efficacy and safety of asenapine in treating manic episodes in elderly inpatients.

Main Methods:

  • An open-label, 3-week study involving 34 elderly patients (mean age 67.2 years) with manic episodes.
  • Inclusion criteria included DSM-IV diagnosis of mania, age over 60, inpatient severity, baseline Young Mania Rating Scale (YMRS) score >20, and no prior asenapine use.
  • Asenapine dosage started at 5 mg twice daily, increasing to 10 mg twice daily by day 21.

Main Results:

  • Twenty-five patients completed the study.
  • The mean YMRS score significantly decreased from 27.0 to 13.3 (p<0.001), with 56% achieving remission (YMRS <12).
  • Mean sleep duration increased, and the Montgomery-Åsberg Depression Rating Scale (MADRS) score decreased.

Conclusions:

  • Asenapine shows tentative efficacy in reducing acute manic symptoms and achieving remission in elderly patients.
  • Careful consideration is necessary for elderly individuals with comorbid physical health conditions.