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Published on: November 19, 2018
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A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization.
Huan-ling Wu1, David H Bremner2, He-yu Li3
1College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; Jiuzhou College of Pharmacy, Yancheng Institute of Industry Technology, Yancheng 224005, PR China.
Summary
This study developed drug-loaded polyacrylonitrile (PAN) microfibers for enhanced delivery, showing potential for multifunctional textiles. The microfibers demonstrated good cytocompatibility and controlled release properties, with no cytotoxicity observed.
Area of Science:
- Materials Science
- Biomedical Engineering
- Textile Science
Background:
- Wet-spun microfibers offer potential for controlled release applications.
- Curcumin (Cur) and vitamin E acetate (Vit. E Ac) were selected as model drugs for evaluating enhanced delivery systems.
- Polyacrylonitrile (PAN) was used as the base material for microfiber fabrication.
Purpose of the Study:
- To develop and characterize drug-loaded polyacrylonitrile (PAN) microfibers for enhanced drug delivery.
- To evaluate the morphological, mechanical, thermal, and drug release properties of the fabricated microfibers.
- To assess the in-vitro cytocompatibility of the drug-loaded microfibers for biomedical applications.
Main Methods:
- Improved wet-spinning method to produce drug-loaded PAN microfibers.
- Fabrication of microfibers into woven fabrics.
- Characterization using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), mechanical testing, thermogravimetric analysis (TGA), and in-vitro drug release studies.
- In-vitro cytocompatibility testing on L929 cells.
Main Results:
- Drug-loaded microfibers exhibited a lobed "kidney" shape with a rough surface and microvoids.
- XRD and FTIR confirmed successful encapsulation and even dispersion of Curcumin and Vitamin E acetate within the PAN fibers.
- Mechanical properties showed slightly improved breaking strength and significantly increased tensile elongation.
- In-vitro drug release was low and sustained over time.
- No cytotoxicity was observed on L929 cells up to 5% (Curcumin) and 10% (Vitamin E acetate) theoretical drug loading content (TDLC).
Conclusions:
- The developed wet-spun drug-loaded PAN microfibers are suitable for multifunctional controlled release materials.
- The microfibers demonstrate promising potential for enhanced drug delivery in biomedical applications.
- Further development of these multifunctional textiles could lead to advancements in the biomedical material field.
