Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

6.2K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
6.2K
The Bone Matrix01:18

The Bone Matrix

8.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
8.2K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

3.3K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
3.3K
Fibril-associated Collagen01:11

Fibril-associated Collagen

3.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MAPLE Deposition of Resorbable Calcium Phosphates on Electrospun Nylon Nanofibres for Bone Tissue Engineering.

Materials (Basel, Switzerland)·2026
Same author

Gadolinium-Doped Iron Oxide Nanoparticles Enhance Radiosensitivity in Melanoma Models Associated with Metabolic Dysfunction.

Pharmaceutics·2026
Same author

<i>Green</i>-Synthesized Zinc Oxide-Bacterial Cellulose Composites: Eco-Friendly Antibacterial Wound Dressings for Faster Healing.

Polymers·2026
Same author

3D Bioprinting of Blood Vessel Model for Improving Wound Healing.

International journal of molecular sciences·2026
Same author

Antimicrobial Nanomaterials in the Food Industry: Applications in Meat Packaging.

Materials (Basel, Switzerland)·2026
Same author

Influence of Precursor Nature on the Properties of Hydroxyapatite-Zirconia Nanocomposites.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 24, 2026

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.6K

New Coll-HA/BT composite materials for hard tissue engineering.

Andrei Vlad Zanfir1, Georgeta Voicu1, Cristina Busuioc1

  • 1Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, "Politehnica" University of Bucharest, 1-7 Gh. Polizu Street, RO-011061 Bucharest, Romania.

Materials Science & Engineering. C, Materials for Biological Applications
|March 9, 2016
PubMed
Summary

New collagen-hydroxyapatite/barium titanate composites show excellent bone regeneration potential. These advanced biomaterials enhance osseointegration, offering promising applications in bone scaffold development.

Keywords:
BiomaterialsCollagen mineralizationComposite materialsHard tissue scaffoldsWet-chemical synthesis

More Related Videos

An Improved Method for the Preparation of Type I Collagen From Skin
05:17

An Improved Method for the Preparation of Type I Collagen From Skin

Published on: January 21, 2014

23.5K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.1K

Related Experiment Videos

Last Updated: Mar 24, 2026

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

21.6K
An Improved Method for the Preparation of Type I Collagen From Skin
05:17

An Improved Method for the Preparation of Type I Collagen From Skin

Published on: January 21, 2014

23.5K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.1K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Orthopedic Research

Background:

  • Bone scaffolds require materials that promote osseointegration.
  • Ceramic powders like hydroxyapatite enhance bone regeneration.
  • Barium titanate's properties may further improve scaffold performance.

Purpose of the Study:

  • Synthesize and characterize novel collagen-hydroxyapatite/barium titanate (Coll-HA/BT) composite materials.
  • Evaluate the biocompatibility and bioactivity of these new composites for bone tissue engineering.
  • Investigate the influence of barium titanate on collagen mineralization and osteoinductivity.

Main Methods:

  • Barium titanate (BT) nanopowder synthesized using sol-gel and hydrothermal methods.
  • Collagen-hydroxyapatite/barium titanate (Coll-HA/BT) composites fabricated from BT nanopowder, hydroxyapatite (HA) nanopowder, and collagen (Coll) gel.
  • Material characterization via X-ray diffraction, Raman spectroscopy, SEM, and TEM.
  • In vitro biocompatibility and bioactivity assessments.

Main Results:

  • Synthesized BT particles displayed spherical morphology (approx. 35 nm) with pseudo-cubic or tetragonal symmetry.
  • Diffraction spectra confirmed significant interaction between collagen and mineral phases, indicating good collagen fiber mineralization.
  • In vitro tests demonstrated excellent osteoinductive properties, particularly for Coll-HA/BT composites.

Conclusions:

  • Collagen-hydroxyapatite/barium titanate composites are successfully synthesized and characterized.
  • The composites exhibit good collagen mineralization and excellent in vitro osteoinductive properties.
  • Barium titanate incorporation enhances the potential of collagen-hydroxyapatite scaffolds for bone regeneration.