Systemic Inflammation and Autoimmunity in Women with Chronic Endometritis
Vitaly A Kushnir1,2, Shirley Solouki3, Tal Sarig-Meth4
1The Center for Human Reproduction, New York, NY, USA.
Summary
Chronic endometritis (CE) and immune markers are common in women with recurrent pregnancy loss (RPL) and/or implantation failure (RIF). However, CE cannot be predicted by peripheral inflammatory or autoimmune markers.
Area of Science:
- Reproductive immunology
- Gynecologic pathology
Background:
- Recurrent pregnancy loss (RPL) and implantation failure (RIF) significantly impact reproductive outcomes.
- Chronic endometritis (CE), systemic inflammation, and autoimmunity are potential contributors to RPL/RIF.
- Understanding the prevalence and interrelation of these factors is crucial for diagnosis and management.
Purpose of the Study:
- To determine the prevalence of CE, systemic inflammation, and autoimmunity in women with RPL/RIF.
- To investigate the relationship between CE and markers of systemic inflammation and autoimmunity.
Main Methods:
- A retrospective study of 55 women with RPL/RIF.
- Assessment of inflammatory markers (adiponectin, CRP, leptin, IL6) and autoimmune markers (immunoglobulins, ANA, thyroid antibodies, antiphospholipid antibodies).
- Diagnosis of CE via endometrial biopsy (CD138-positive plasma cells).
Main Results:
- 45.5% of women with RPL/RIF were diagnosed with CE.
- 32.7% showed at least one positive inflammatory marker, and 61.8% showed at least one autoimmune marker.
- No significant difference in systemic inflammatory or autoimmune profiles was observed between women with and without CE.
Conclusions:
- CE and elevated inflammatory/autoimmune markers are prevalent in women with RPL/RIF.
- Peripheral inflammatory and autoimmune markers do not reliably predict the presence of CE.
- Further research may be needed to elucidate the complex interplay of these factors in reproductive failure.
Keywords:
Autoimmunitychronic endometritisinfertilityinflammationrecurrent implantation failurerecurrent pregnancy lossMore Related Videos
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