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Clozapine-induced palilalia?.

Jacinto C Azevedo1, Rui Lopes2, Rosário Curral1

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Summary
This summary is machine-generated.

Palilalia, a speech disorder involving word repetition, can be a rare side effect of clozapine treatment for schizophrenia. Lowering clozapine dosage resolved palilalia in a patient with schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Palilalia is an acquired speech disorder characterized by involuntary repetition of words or phrases.
  • It is associated with various neurological and psychiatric conditions, including schizophrenia.

Purpose of the Study:

  • To report a rare case of palilalia.
  • To investigate the potential link between clozapine and palilalia in a patient with schizophrenia.

Main Methods:

  • Case study of a 28-year-old male patient with refractory schizophrenia.
  • Patient was treated with 300 mg of clozapine, leading to the development of palilalia.
  • Diagnostic evaluations included electroencephalogram (EEG), blood tests, and magnetic resonance imaging (MRI).

Main Results:

  • The patient developed palilalia during clozapine treatment.
  • EEG showed nonspecific alterations; blood tests and MRI were normal.
  • Palilalia resolved upon reduction of the clozapine dosage.

Conclusions:

  • Clozapine-induced palilalia is a rare pharmacologic side effect.
  • Clinicians should consider this adverse effect when patients present with palilalia during clozapine therapy.