Related Experiment Video
Updated: Mar 24, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Complete Penile Necrosis in a Patient With Heparin-induced Thrombocytopenia: A Case Report
Anne-Sophie Blais1, Marie-Pier Deschênes Rompré1, Louis Lacombe1
1Division of Urology, Centre Hospitalier Universitaire de Québec (CHU), Université Laval, Québec City, Québec, Canada.
Abstract:
Penile necrosis is a rare condition that has been mostly described in association with diabetes mellitus and end-stage renal disease. We report an unusual case of acute penile necrosis because of heparin-induced thrombocytopenia. A 75-year-old man presented with acute renal failure and experienced cardiac complications during the hospitalization. The patient was treated twice with intravenous heparin. He developed symptoms of penile necrosis 4 days after the reintroduction of heparin. At that moment, the platelet count dropped by 61%, and the analysis of heparin-pf4 antibodies was positive for heparin-induced thrombocytopenia. The patient underwent a total penectomy and a perineal urethrostomy.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis IV: Nursing Management
Cardiac Catheterization I: Pre-Procedure Overview
Peripheral Artery Disease V: Postoperative Nursing Management
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism III: Nursing Management

