Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

672
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
672
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.5K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.5K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
Depressants01:28

Depressants

574
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
574
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

613
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
613

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral perfusion and the risk of cognitive decline and dementia in community dwelling older people.

Cerebral circulation - cognition and behavior·2022
Same author

The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy - A Pooled Analysis of Two Randomized Controlled Trials.

The journal of prevention of Alzheimer's disease·2022
Same author

The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2021
Same author

[Practice variation in diagnostic testing for dementia; a nation-wide overview].

Nederlands tijdschrift voor geneeskunde·2021
Same author

Predictive value of traditional risk factors for cardiovascular disease in older people: A systematic review.

Preventive medicine·2020
Same author

Systemic infection and microglia activation: a prospective postmortem study in sepsis patients.

Immunity & ageing : I & A·2019

Related Experiment Video

Updated: Mar 24, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.3K

Alcoholism and dementia.

W A van Gool

    Acta Neuropsychiatrica
    |March 10, 2016
    PubMed
    Summary
    This summary is machine-generated.

    The concept of alcoholic dementia is debated. A specific group of alcoholics exhibits dementia symptoms, supporting a clinical diagnosis separate from direct alcohol neurotoxicity.

    More Related Videos

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
    19:57

    The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

    Published on: August 5, 2017

    8.9K

    Related Experiment Videos

    Last Updated: Mar 24, 2026

    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
    09:26

    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

    Published on: February 6, 2019

    22.3K
    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

    Published on: June 23, 2023

    1.7K
    The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
    19:57

    The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

    Published on: August 5, 2017

    8.9K

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Clinical Neurology

    Background:

    • The term 'alcoholic dementia' is controversial, with limited contribution from neuroradiological and neuropathological studies.
    • Clinical observations suggest a subset of alcoholics presents with dementia, characterized by diverse psychological disturbances beyond amnesia.

    Purpose of the Study:

    • To review the controversy surrounding 'alcoholic dementia'.
    • To evaluate the utility of existing diagnostic frameworks for cognitive impairment in alcoholics.

    Main Methods:

    • Review of clinical descriptions of cognitive disturbances in alcoholics.
    • Analysis of the nosological implications of 'alcoholic dementia' versus syndromal diagnoses.

    Main Results:

    • Neuroradiological and neuropathological evidence offer minimal resolution to the 'alcoholic dementia' debate when dementia is viewed clinically.
    • A distinct sub-population of alcoholics meets the criteria for dementia, exhibiting a range of psychological symptoms.

    Conclusions:

    • The nosological concept of 'alcoholic dementia' is problematic due to its implication of direct neurotoxicity and unanswered pathogenetic questions.
    • The DSM-III-R category 'dementia associated with alcoholism' provides a clinically descriptive and syndromally accurate diagnosis without presuming etiological mechanisms.