Influence of Propofol on the Mood - a comparative study
P J Keyzer1, J D'haese2, H A D'haenen1
1kliniekhoofd,Dienst Psychiatric AZ,VUB.
Acta Neuropsychiatrica
|March 10, 2016
Summary
Propofol anesthesia positively impacts patient mood, leading to increased elation and composure compared to methohexitone. This suggests propofol offers a favorable mood profile for surgical patients.
Area of Science:
- Anesthesiology
- Psychopharmacology
Background:
- Electroconvulsive therapy (ECT) often requires anesthesia.
- Understanding anesthetic effects on patient mood is crucial for optimizing ECT procedures.
- Propofol is a commonly used anesthetic agent with potential mood-altering properties.
Purpose of the Study:
- To evaluate the influence of propofol on mood compared to methohexitone.
- To assess the suitability of propofol as an anesthetic for electroconvulsive therapy based on mood outcomes.
Main Methods:
- A study involving 80 psychologically healthy subjects.
- Mood assessment before and 4 hours post-anesthesia using the Profile of Mood States (POMS).
- Comparison of mood changes between patients receiving propofol versus methohexitone anesthesia.
Main Results:
- The propofol group reported significantly higher elation (factor 1) from 1 to 4 hours post-anesthesia (p<0.01).
- Propofol recipients were more composed (factor 4) at 1 hour (p<0.01) and agreeable (factor 2) at 2 hours (p<0.05) compared to methohexitone.
- Patients under propofol anesthesia experienced less fatigue (factor 3) and confusion (factor 5).
Conclusions:
- Propofol demonstrates a favorable influence on various mood aspects compared to methohexitone.
- These findings support the potential use of propofol as an anesthetic for electroconvulsive therapy, considering its positive mood effects.
More Related Videos
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
2.7K
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
14.6K
Related Concept Videos
01:24Parenteral Anesthetics: Overview
908
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
908
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
805
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
805
01:23Sedatives and Hypnotics: Overview
1.9K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.9K
01:20Sedatives and Hypnotics Drugs: Barbiturates
1.3K
Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
1.3K
01:24General Anesthesia: Overview
978
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
978
01:19Sedatives and Hypnotics Drugs: Benzodiazepines
1.2K
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
1.2K