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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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Elevated systemic galectin-1 levels characterize HELLP syndrome.

Annegret Schnabel1, Sandra M Blois2, Peter Meint1

  • 1Krankenhaus Barmherzige Brüder - Frauenklinik St. Hedwig, Department of Obstetrics and Gynecology, University of Regensburg, Regensburg, Germany.

Journal of Reproductive Immunology
|March 10, 2016
PubMed
Summary
This summary is machine-generated.

Systemic galectin-1 (gal-1) and sFlt-1 levels are elevated in HELLP syndrome patients, while PlGF levels decrease. Increased gal-1 may aid in predicting HELLP syndrome development.

Keywords:
Angiogenic factorsGalectin-1HELLPPregnancy

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Area of Science:

  • Reproductive biology
  • Immunology
  • Biochemistry

Background:

  • Galectin-1 (gal-1) is crucial during gestation.
  • Gal-1 is upregulated in HELLP patient placentas, but systemic levels are unclear.
  • HELLP syndrome is a severe pregnancy complication.

Purpose of the Study:

  • To investigate systemic galectin-1 (gal-1) levels in HELLP syndrome.
  • To assess the relationship between gal-1, placental growth factor (PlGF), and soluble fms-like tyrosine kinase 1 (sFlt-1) in HELLP.
  • To correlate these factors with HELLP syndrome severity.

Main Methods:

  • Systemic galectin-1 (gal-1), PlGF, and sFlt-1 levels were measured in early- and late-onset HELLP patients and healthy controls.
  • Statistical analyses were performed to compare groups and identify correlations.

Main Results:

  • Systemic gal-1 and sFlt-1 levels were significantly higher in HELLP patients (early and late onset) compared to controls.
  • Peripheral PlGF levels were decreased in both early- and late-onset HELLP patients.
  • A positive correlation was observed between systemic gal-1 and sFlt-1/PlGF ratios in early-onset HELLP.

Conclusions:

  • HELLP syndrome is associated with increased circulating galectin-1 (gal-1).
  • Systemic gal-1 levels may serve as a predictive biomarker for HELLP syndrome development.
  • Integrating gal-1 measurements could enhance HELLP syndrome diagnostic strategies.