Related Experiment Video

Updated: Mar 24, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K

Successfully treated infective endocarditis caused by methicillin-resistant Staphylococcus Aureus in extremely low

Sehwa Jung1, Kyung Uk Jeong1, Jang Hoon Lee1

  • 1Division of Neonatology, Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.

Korean Journal of Pediatrics
|March 10, 2016
PubMed

Insights

Central venous catheters in preterm infants can lead to serious infections like endocarditis. Early echocardiogram surveillance in extremely low birth weight infants may help detect and treat these conditions effectively.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Infectious Diseases

Background:

  • Survival rates for preterm infants have improved significantly.
  • Central venous catheters are crucial for neonatal intensive care but pose risks.
  • These catheters increase the likelihood of intracardiac thrombosis and serve as a breeding ground for bacteria during septicemia.

Purpose of the Study:

  • To report a case of methicillin-resistant Staphylococcus aureus endocarditis in an extremely low birth weight infant.
  • To highlight the role of echocardiography in diagnosing catheter-related complications.
  • To propose a surveillance strategy for early detection of endocarditis in high-risk neonates.

Main Methods:

  • Case report of an extremely low birth weight infant with persistent bacteremia.
  • Echocardiogram to identify intracardiac vegetation.
  • Treatment with targeted antibiotic therapy.

Main Results:

  • Persistent bacteremia due to methicillin-resistant Staphylococcus aureus was identified.
  • Echocardiogram revealed vegetation consistent with endocarditis.
  • Successful treatment with antibiotics resulted in patient recovery without major complications.

Conclusions:

  • Endocarditis is a potential complication of central venous catheter use in extremely low birth weight infants.
  • Surveillance echocardiography shortly after birth and during sepsis episodes is recommended.
  • Early diagnosis and antibiotic treatment are critical for favorable outcomes in neonates.

Keywords:
Central venous catheterizationEndocarditisExtremely low birth weight infantMethicillin-resistant Staphylococcus aureus

More Related Videos

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.1K

Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
740
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
33
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
25
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
329
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
561
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
60