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Severe Thrombotic Complication of Eltrombopag in a Cirrhotic Patient

Alexandra J Baumann1, David S Wheeler1, Gabor Varadi2

  • 1Department of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA.

ACG Case Reports Journal
|March 10, 2016
PubMed

We present a patient with hepatitis C virus (HCV) and cirrhosis who was treated with eltrombopag for idiopathic thrombocytopenic purpura and was incidentally found to have a right atrial thrombus with extension into the left internal jugular vein. Eltrombopag was discontinued and the patient was treated with thrombectomy and anticoagulation. Given the proposed use of eltrombopag in HCV-associated thrombocytopenia, we advise caution when treating cirrhotics who are at higher intrinsic risk of thrombosis.

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