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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
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Postradiation angiosarcoma of bladder with extensive osseous metaplasia
Hima Bindu Rallabandi1, Meenakshi Swain, Swarnalata Gowrishankar
1Department of Histopathology, Apollo Hospital, Hyderabad, Telangana, India.
Indian Journal of Pathology & Microbiology
|March 11, 2016
Summary
This case report details a rare bladder angiosarcoma in a 65-year-old woman. The tumor, presenting with hematuria, showed extensive osseous metaplasia and occurred 22 years after radiotherapy.
Area of Science:
- Oncology
- Pathology
Background:
- Angiosarcomas are rare vascular tumors, comprising less than 2% of all sarcomas.
- Bladder angiosarcomas are exceptionally rare, with limited cases reported in medical literature.
Observation:
- A 65-year-old female presented with hematuria, indicative of a bladder tumor.
- Imaging revealed a calcified bladder mass; cystoscopy confirmed a calcified lesion.
- The patient had a history of cervical carcinoma treated with surgery and radiotherapy 22 years prior.
Findings:
- Histopathological examination of the bladder mass revealed a high-grade epithelioid sarcoma with extensive osseous metaplasia.
- Immunohistochemical analysis showed the tumor was positive for CD31 and vimentin, and negative for cytokeratin, desmin, and CD34.
- This represents the first reported case of bladder angiosarcoma occurring 22 years post-radiotherapy with significant osseous metaplasia.
Implications:
- This case expands the understanding of rare bladder angiosarcomas and their potential latency after radiation therapy.
- The presence of extensive osseous metaplasia in this radiation-induced angiosarcoma warrants further investigation.
- Highlights the importance of considering angiosarcoma in the differential diagnosis of bladder tumors, especially in patients with a history of pelvic radiotherapy.
