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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

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Published on: May 27, 2020

Methylene blue modulates functional connectivity in the human brain.

Pavel Rodriguez^1,2, Amar P Singh³, Kristen E Malloy⁴

¹Research Imaging Institute, The University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA. rodriguezp3@uthscsa.edu.

Brain Imaging and Behavior

|March 11, 2016

Summary

Low-dose Methylene blue (MB) modulates human brain networks. This study reveals MB impacts task-related and resting-state functional connectivity, suggesting potential for cognitive enhancement and further research.

Keywords:

Default mode network Evoked response Functional connectivity Methylene blue Multimodal fMRI

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Area of Science:

Neuroscience
Pharmacology

Background:

Methylene blue (MB) is an FDA-approved drug for specific poisonings.
MB has shown potential for memory enhancement and increased fMRI BOLD response in rodents.
Neural mechanisms of MB's effects in the human brain remain unclear.

Purpose of the Study:

To investigate the effects of a single low oral dose of Methylene blue (MB) on neural network functional connectivity in healthy adults.
To test the hypothesis that MB modulates brain networks.

Main Methods:

Randomized, double-blinded, placebo-controlled design.
Task-based and resting-state functional magnetic resonance imaging (fMRI) performed before and after MB or placebo administration.
Utilized visuomotor task to assess task-related network activity.

Main Results:

MB administration led to reduced cerebral blood flow in a task-related network during a visuomotor task.
MB enhanced resting-state functional connectivity in regions involved in perception and memory.
Demonstrated modulation of both task-related and resting-state neural networks.

Conclusions:

Low-dose Methylene blue modulates functional connectivity in human brain networks.
Findings support MB's potential in cognitive function and warrant further investigation in various populations.
Provides novel neuroimaging evidence for MB's central nervous system effects.