Related Experiment Video
Updated: Aug 19, 2026
A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
Published on: December 26, 2016
Penile cancer metastasizing to the breast: a case report
Gianluca Franceschini1, Alejandro Martin Sanchez2, Alba Di Leone2
1Multidisciplinary Breast Center, Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Largo Agostino Gemelli, 8, Roma, 00168, Italy. franceschinigianluca@gmail.com.
Background:
Penile cancer is a relatively uncommon cancer in developed nations. Metastatic disease is rare, but lymphatic or vascular spreading has been previously reported to the liver, lungs, bones, brain, heart and skin.
Case Presentation:
We report a case of a 49-year-old white man with a penile squamous cell carcinoma previously treated with partial penectomy and bilateral inguinal lymph node dissection, followed by adjuvant therapy. Three years after treatment, the primitive neoplasm metastasized to the breast, presenting as a painful lump. Differentials of a secondary versus a malignant primary tumor were considered and in view of a diagnostic dilemma the lesion was excised.
Conclusions:
This case is unusual in its site of metastatic progression as well as in its pattern of clinical presentation. Awareness of such a condition by physicians is mandatory in order to make an early diagnosis and start prompt and correct therapeutic planning.
