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An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
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Human Dorsolateral Prefrontal Cortex Is Not Necessary for Spatial Working Memory.

Wayne E Mackey1, Orrin Devinsky2, Werner K Doyle3

  • 1Department of Psychology, New York University, New York, New York 10003.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 11, 2016
PubMed
Summary
This summary is machine-generated.

The dorsolateral prefrontal cortex (dlPFC) is not solely responsible for working memory (WM). Lesions impairing the precentral sulcus (PCS) affect WM accuracy, not dlPFC damage alone.

Keywords:
frontal eye fieldhumanlesionprefrontal cortexsaccadeworking memory

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Area of Science:

  • Cognitive Neuroscience
  • Neurobiology

Background:

  • A dominant theory suggests the dorsolateral prefrontal cortex (dlPFC) is crucial for working memory (WM) maintenance, based on nonhuman primate studies.
  • Human neuroimaging studies often show persistent activity in the precentral sulcus (PCS) during WM delays, creating a discrepancy with the dlPFC theory.

Purpose of the Study:

  • To resolve the discrepancy between primate and human studies regarding the neural basis of WM.
  • To determine the necessity of the dlPFC for WM by examining patients with dlPFC lesions.

Main Methods:

  • Compared performance on a memory-guided saccade task between patients with dlPFC lesions and healthy controls.
  • Utilized a task previously employed in nonhuman primate studies to measure spatial WM.

Main Results:

  • dlPFC lesions only impaired memory-guided saccade accuracy when the precentral sulcus (PCS) was also affected.
  • Damage to dorsolateral dlPFC regions sparing the PCS did not impact WM performance.

Conclusions:

  • The precentral sulcus (PCS), not the entire dlPFC, is the necessary subregion for WM.
  • The influential animal model of human cognition requires revision to accurately reflect the neural substrates of WM in humans.