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Related Concept Videos

Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
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Hormonal Regulation of the Menstrual Cycle01:22

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Ovarian Cycle01:27

Ovarian Cycle

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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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An Overview of the Endocrine System01:10

An Overview of the Endocrine System

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
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The Menstrual Cycle01:19

The Menstrual Cycle

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The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
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Related Experiment Video

Updated: Mar 24, 2026

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
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Recurrent Endocrine Cycles.

James M Minor1, Leslie M Rickey2, Richard M Bergenstal3

  • 11 Diabetes Data Scientist, Newark, DE, USA.

Journal of Diabetes Science and Technology
|March 11, 2016
PubMed
Summary
This summary is machine-generated.

Predicting dangerous blood glucose levels is now possible with new endocrine cycle analysis. This proactive healthcare approach identifies ~7-day patterns to alert patients and doctors to potential acute hyperglycemia events.

Keywords:
diabetesdynamicshyperglycemiahypoglycemiapredictionrecurrent cycles

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Area of Science:

  • Endocrinology
  • Biomedical Engineering
  • Data Science

Background:

  • Blood glucose variability presents significant challenges in diabetes management.
  • Recurrent endocrine cycles have been recently identified, offering potential for predictive healthcare.

Purpose of the Study:

  • To investigate the utility of phase portraits and analytics in detecting recurrent glucose metric cycles.
  • To assess the ability of these cycles to predict serious glycemic conditions.

Main Methods:

  • Analysis of several months of glucose readings and daily metrics from 111 patients and 1 subject.
  • Application of phase portraits and phase analytics to identify cyclical patterns.

Main Results:

  • Detection of recurrent patterns with a cycle rate of approximately 7 days.
  • Development of risk models and plots yielding advanced alerts for acute hyperglycemia.
  • Achieved >96% true-positive detection with a 5% false-positive rate.

Conclusions:

  • A graphical and functional method for implementing advanced glycemic alerts within monitoring systems.
  • Potential to proactively warn healthcare providers and patients of impending critical glucose levels.