[Evaluation of the protective effects of nifedipine and verapamil in patients with bronchial hyperreactivity]

The protective effect was studied of the drugs blocking the calcium channel on histamine-induced bronchospasm. In a group of 107 studied subjects with clinical suspicion of bronchial hyperreactivity in 37 cases hypersensitivity to histamine was diagnosed. The protective effect of one oral dose of nifedipine 20 mg and verapamil 1.6 mg administered by inhalation was assessed. A protective effect of nifedipine was observed in 61% and that of verapamil in 37% of cases. These drugs may be used in the prophylaxis and treatment of bronchospastic conditions.