[Hormonal inhalation preparations in the treatment of bronchial asthma in children]

Area of Science:

• Pediatric Pulmonology
• Respiratory Medicine
• Clinical Pharmacology

Background:

• Severe and long-standing asthma in children presents significant management challenges.
• Systemic corticosteroid use in pediatric asthma can lead to adverse effects.
• Alternative delivery methods for asthma medication are continuously explored.

Purpose of the Study:

• To evaluate the efficacy and safety of inhaled hormonal preparations (Becotide, Beclomet) in children with severe asthma.
• To assess the potential for reducing or eliminating oral corticosteroid dependence.

Main Methods:

• A cohort of 59 children (aged 3-18 years) with severe, persistent asthma received inhaled corticosteroids.
• Treatment outcomes included general condition, dyspnoeic attacks, and the need for oral prednisone.
• Adverse events were monitored throughout the study period.

Main Results:

• A significant improvement in general condition was observed in 70% of the children.
• Complete regression or alleviation of dyspnoeic attacks was noted in the majority of participants.
• Oral prednisone was successfully withdrawn in 15 out of 17 children who were previously on this medication.
• No adverse side effects were reported for Becotide or Beclomet administration.

Conclusions:

• Inhaled corticosteroids (Becotide, Beclomet) are effective and well-tolerated for managing severe pediatric asthma.
• This treatment modality offers a promising alternative to systemic corticosteroids, enabling their discontinuation.
• Further research may explore optimal dosing and long-term outcomes in pediatric populations.