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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
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The HIV-Associated Enteric Microbiome Has Gone Viral
Brent E Palmer1, Sam X Li1, Catherine A Lozupone1
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Cell Host & Microbe
|March 11, 2016
Summary
Human immunodeficiency virus (HIV) infection alters the gut microbiome. Recent studies highlight the enteric virome
Area of Science:
- Microbiology
- Virology
- Gastroenterology
Background:
- HIV infection significantly impacts the gut microbiome, particularly enteric bacteria.
- Knowledge regarding other gut microbiome components in HIV infection remains limited.
Purpose of the Study:
- To investigate the role of the enteric virome in HIV-associated gastroenteritis.
- To elucidate the contribution of the enteric virome to HIV pathogenesis.
Main Methods:
- Analysis of enteric virome composition in individuals with HIV.
- Correlation of virome alterations with gastroenteritis and disease progression.
Main Results:
- The enteric virome plays an under-appreciated role in HIV infection.
- Specific viral alterations are linked to HIV-associated gastroenteritis and pathogenesis.
Conclusions:
- The enteric virome is a critical factor in understanding HIV-associated gastrointestinal complications.
- Targeting the enteric virome may offer new therapeutic strategies for HIV patients.
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