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Updated: Aug 18, 2026

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
Growth and differentiation signals as determinants of cancer cell proliferation
1Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, New York 14263.
Abstract:
The development and the maintenance of a tissue involves the sequential differentiation of precursor cells along multiple intermediate stages of maturity. At these stages the cells can proliferate or differentiate depending upon the growth or differentiation signals they receive. Terminally mature cells lose their ability to proliferate. Alterations can occur at the level of the cell or the whole organism that lead to the sustained proliferation of incompletely mature cells. This process constitutes an oncogenic event, and the cellular and molecular changes that lead to its occurrence are surveyed in this review.
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