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Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
Simon Boggild1,2, Simon Molgaard3,4, Simon Glerup4
1MIND Centre, Stereology and Electron Microscopy Laboratory, Aarhus University, 8000 C, Aarhus, Denmark. simon.boeggild.hansen@post.au.dk.
BMC Cell Biology
|March 12, 2016
Summary
Sortilin and SorCS2, Vps10p receptors, show distinct prenatal expression patterns in mouse peripheral tissues, particularly in developing epithelial and mesodermal tissues, offering new insights into their functions.
Area of Science:
- Developmental Biology
- Molecular Biology
- Genetics
Background:
- Sortilin and SorCS2 belong to the Vps10p receptor family.
- Their roles in nervous tissue are known, but their functions in developing peripheral tissues are unclear.
Purpose of the Study:
- To characterize the prenatal localization of sortilin and SorCS2 in mouse peripheral tissues.
- To understand the expression patterns of these receptors during development.
Main Methods:
- Prenatal expression analysis
- Localization studies in mouse embryos
Main Results:
- Sortilin is highly expressed in developing lung, kidney, pancreas, salivary gland, and bile ducts.
- SorCS2 is primarily found in mesodermally derived tissues like muscle, adipose tissue, and connective tissue, as well as lung epithelia.
Conclusions:
- The distinct expression patterns suggest diverse developmental roles for Sortilin and SorCS2.
- This study provides a foundation for generating new hypotheses regarding the Vps10p receptor family's functions.
