Related Experiment Video
Updated: Mar 24, 2026
07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
1.3K
Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?
Reinier A Boon1, Nicolas Jaé2, Lesca Holdt3
1Institute for Cardiovascular Regeneration, University of Frankfurt, Frankfurt, Germany; German Center of Cardiovascular Research, Berlin, Germany.
Journal of the American College of Cardiology
|March 12, 2016
Summary
Long noncoding RNAs (lncRNAs) are key regulators in cardiovascular diseases, influencing functions and acting as potential biomarkers. This review summarizes lncRNA roles in heart conditions and disease progression.
Area of Science:
- Genomics
- Molecular Biology
- Cardiovascular Research
Background:
- The human genome is largely transcribed, with a small fraction encoding proteins.
- Long noncoding RNAs (lncRNAs) are a diverse class of transcripts with emerging functional roles.
- Genetic variations in lncRNAs are linked to cardiovascular disease susceptibility.
Purpose of the Study:
- To review the current understanding of lncRNA functions in cardiovascular diseases.
- To explore the potential of lncRNAs as biomarkers for cardiac conditions.
Main Methods:
- Literature review of recent studies on lncRNAs and cardiovascular diseases.
- Analysis of lncRNA regulation in disease states.
- Examination of lncRNA roles as microRNA sponges and epigenetic regulators.
Main Results:
- lncRNAs like ANRIL, MALAT1, MIAT, and lincRNA-p21 are implicated in cardiovascular disease pathogenesis.
- Specific lncRNAs regulate endothelial cell function, diabetic retinopathy, neointima formation, and ischemia-reperfusion injury.
- lncRNAs function as microRNA sponges and epigenetic regulators in cardiac tissue.
Conclusions:
- lncRNAs play significant roles in cardiovascular health and disease.
- lncRNAs hold promise as diagnostic and prognostic biomarkers for cardiovascular diseases.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
02:39lncRNA - Long Non-coding RNAs
3.8K
3.8K
01:29Pharmacogenomics: Identification of New Drug Targets
76
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
76
01:20Types of RNA
16.2K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
16.2K
01:23Types of RNA
73.8K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.8K
03:18Non-LTR Retrotransposons
14.0K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
14.0K