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Relationship Between 18F-FDG PET/CT Findings and HER2 Expression in Gastric Cancer
Ruohua Chen1, Xiang Zhou1, Jianjun Liu2
1Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Cancer Metabolism, Institute of Health Sciences, Chinese Academy of Sciences, and School of Medicine, Shanghai Jiao Tong University, Shanghai, China; and.
¹⁸F-FDG uptake in gastric cancer correlates with human epidermal growth factor receptor 2 (HER2) expression. This suggests ¹⁸F-FDG PET/CT may help predict HER2 status and guide anti-HER2 therapy selection.
Area of Science:
- Oncology
- Nuclear Medicine
- Molecular Imaging
Background:
- Human epidermal growth factor receptor 2 (HER2) status is crucial for guiding anti-HER2 therapy in gastric cancer.
- The relationship between ¹⁸F-FDG uptake and HER2 expression in gastric cancer remains underexplored.
- ¹⁸F-FDG PET/CT is a widely used imaging modality for malignant tumors.
Purpose of the Study:
- To investigate the association between ¹⁸F-FDG uptake and HER2 expression in gastric cancer.
- To determine if ¹⁸F-FDG PET/CT can predict HER2 status in gastric cancer patients.
Main Methods:
- Retrospective analysis of 64 gastric cancer patients who underwent ¹⁸F-FDG PET/CT prior to surgery.
- Calculation of maximum standardized uptake value (SUVmax) from ¹⁸F-FDG PET/CT scans.
- Correlation analysis between SUVmax and HER2 expression, with exclusion of signet-ring cell carcinoma.
Main Results:
- No significant correlation between SUVmax and HER2 expression was initially found.
- Excluding signet-ring cell carcinoma, SUVmax was significantly higher in HER2-negative than HER2-positive tumors (P=0.021).
- Multivariate analysis identified SUVmax and tumor differentiation as significant predictors of HER2 expression (P=0.048 and P=0.028, respectively).
- An SUVmax cutoff of 6.2 predicted HER2 expression with 64.4% accuracy.
Conclusions:
- ¹⁸F-FDG uptake in gastric cancer is associated with HER2 expression.
- ¹⁸F-FDG PET/CT may serve as a valuable tool for predicting HER2 status.
- This imaging modality could aid in optimizing therapeutic strategies for gastric cancer.
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