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Related Concept Videos

Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Related Experiment Video

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Development of New Therapeutic Applications Using Microfluidics
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Communication in Drug Development: "Translating" Scientific Discovery.

Jeff Settleman1, Robert L Cohen1

  • 1Calico Life Sciences, 1170 Veterans Boulevard, South San Francisco, CA 94080, USA.

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|March 12, 2016
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Summary

Developing new medicines is hard. This commentary outlines essential communication strategies for translating biological discoveries into approved drug therapies, addressing key challenges and opportunities.

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Area of Science:

  • Drug discovery and development
  • Translational science
  • Pharmaceutical research

Background:

  • Developing novel therapeutics to improve human health and longevity is a complex scientific and logistical challenge.
  • Translating basic biological discoveries into clinically effective drugs requires overcoming significant hurdles.

Purpose of the Study:

  • To identify critical communication elements for successful drug development.
  • To discuss challenges and opportunities in translating biological findings into approved therapies.

Main Methods:

  • This commentary synthesizes current understanding of the drug development pipeline.
  • It analyzes communication strategies essential for interdisciplinary collaboration.

Main Results:

  • Effective communication is crucial for bridging the gap between biological research and clinical application.
  • Key communication elements include clear data sharing, stakeholder alignment, and regulatory navigation.

Conclusions:

  • Optimizing communication pathways can accelerate the translation of promising research into life-saving medicines.
  • Addressing communication challenges is vital for advancing pharmaceutical innovation and improving patient outcomes.