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Published on: December 6, 2016
Polysomnography results in pediatric patients with mild obstructive sleep apnea: Adenotonsillectomy vs. watchful
Samuel J Trosman1, David J Eleff2, Jyoti Krishna3
1Head and Neck Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, United States.
Insights
Adenotonsillectomy significantly improves the apnea-hypopnea index in children with mild obstructive sleep apnea (OSA). This treatment is especially effective for non-obese, non-syndromic children compared to observation.
Area of Science:
- Pediatric Sleep Medicine
- Otolaryngology
- Respiratory Medicine
Background:
- Mild obstructive sleep apnea (OSA) in children lacks established treatment guidelines.
- Current data on optimal management strategies for pediatric mild OSA is limited.
Purpose of the Study:
- To compare the effectiveness of adenotonsillectomy versus observation for treating mild obstructive sleep apnea in pediatric patients.
- To analyze changes in the apnea-hypopnea index (AHI) following each treatment approach.
Main Methods:
- Retrospective chart review of children aged 9 months to 9 years with mild OSA (AHI 1-5).
- Inclusion of patients with at least two polysomnograms from 1999-2013.
- Comparison of outcomes between patients who underwent adenotonsillectomy and those managed with watchful waiting.
Main Results:
- Adenotonsillectomy improved the mean AHI from 3.50 to 2.69, while the observation group's mean AHI worsened from 3.09 to 5.18.
- Surgical intervention showed a significant improvement in AHI (p=0.03), particularly in non-obese, non-syndromic children (p=0.04).
- No significant AHI improvement was observed in obese (p=0.25) or syndromic (p=0.36) patients following adenotonsillectomy compared to observation.
Conclusions:
- Adenotonsillectomy offers significant improvement in polysomnographic outcomes for pediatric mild OSA, especially in non-obese, non-syndromic populations.
- Observation alone may lead to worsening AHI in some children with mild OSA.
- Further prospective, randomized trials are needed to establish definitive treatment guidelines for pediatric mild OSA.
Objective:
There is a lack of consensus and a paucity of data regarding how to best treat pediatric patients with mild obstructive sleep apnea. The objective of our study was to compare outcomes following adenotonsillectomy vs. observation in children with mild obstructive sleep apnea based on polysomnography results.
Methods:
A retrospective chart review was performed on children ages 9 months to 9 years with 2 or more polysomnograms completed at a tertiary care academic center. Children diagnosed with mild obstructive sleep apnea (obstructive apnea-hypopnea index 1-5) on polysomnography performed from 1999 to 2013 were included. Patients underwent adenotonsillectomy or watchful waiting for obstructive sleep apnea. The primary outcome was the change in apnea-hypopnea index.
Results:
There were 62 patients who met inclusion criteria for the study; 19 of the 62 patients were obese, while 15 had a craniofacial syndrome or hypotonia. Eighteen patients underwent adenotonsillectomy for mild obstructive sleep apnea while 44 were observed. The mean apnea-hypopnea index of patients after adenotonsillectomy improved from 3.50 (95% Confidence Interval [CI] 2.97-4.03) to 2.69 (95% CI 1.48-3.90), while the mean apnea-hypopnea index of the observation group worsened from 3.09 (95% CI 2.76-3.42) to 5.18 (95% CI 2.46-7.90). Between-group analysis showed significant improvement in the surgery group (p=0.03), with a persistent improvement on multivariate analysis adjusting for baseline apnea-hypopnea index (p=0.05). This difference was seen mostly in non-obese, non-syndromic children (p=0.04). There was no significant difference between groups amongst obese (p=0.25) and syndromic (p=0.36) patients.
Conclusions:
Adenotonsillectomy leads to a significant improvement in apnea-hypopnea index on follow-up polysomnography over an observational approach, especially in non-obese, non-syndromic children. A prospective, randomized trial is necessary to help determine appropriate treatment strategies for pediatric mild obstructive sleep apnea.
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