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Related Experiment Videos

[Insulin--its past, present and future].

M Grujić, Z Hrisafović, I Kulenović

    Medicinski Arhiv
    |January 1, 1989
    PubMed
    Summary

    Researchers are developing purer forms of insulin and advanced delivery systems like artificial pancreas devices for better diabetes treatment. While closed systems offer glucose-insulin feedback, current technology is too large for practical daily use.

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    [Hemorheologic changes in diabetes mellitus].

    Medicinski arhiv·1992

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Medical Technology

    Context:

    • Insulin purification techniques have evolved significantly since its discovery.
    • Conventional insulins can exhibit significant antigenicity, posing challenges in treatment.
    • Advancements in diabetes mellitus management are crucial for patient care.

    Purpose:

    • To review the progress in insulin purification and therapeutic applications.
    • To discuss the evolution of insulin delivery systems for diabetes treatment.
    • To highlight the potential of artificial pancreas systems in normalizing glycemia.

    Summary:

    • Gel-filtration and ion-exchange chromatography yield highly purified monocomponent insulin with reduced antigenicity.
    • Semisynthesis and genetic engineering have enabled the production of human insulin, advancing treatment.
    • Intensified insulin therapy includes repeated injections, insulin pumps (open systems), and artificial pancreas (closed systems).
    • Closed systems, operating on a glucose-insulin feedback principle, offer complete glycemia normalization but face size limitations for practical use.

    Impact:

    • Purified insulins and advanced delivery systems improve diabetes management and patient outcomes.
    • The development of artificial pancreas technology promises a future of closed-loop glucose control.
    • Current technological constraints hinder the widespread adoption of fully automated insulin delivery systems.

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