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Updated: Mar 24, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
An unusual presentation of recurring metastatic melanoma
Rose Park1, Kira Vincent1, Abd A Abdelrahman2
1Creighton University School of Medicine, Omaha, NE 68131, USA.
Abstract:
A 53-year-old non-distressed Caucasian female complains of dyspnea and palpitations for 5 days. Past medical history includes Stage IV melanoma with adequate resection 23 years prior. The patient suddenly became increasingly tachycardic in mild respiratory distress while maintaining hemodynamic stability. TTE depicted 10.5 × 7.5 × 9.5 cm(3) mass within her left ventricle and a large volume of pericardial effusion, which progressed to cardiac tamponade. Pericardial window was performed. Metastatic involvement should be ruled out for all symptomatic patients with a history of melanoma.
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