Related Experiment Video
Updated: Mar 24, 2026
05:48
The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
6.6K
Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a
Kathryn Eve Lewandowski1, Sarah H Sperry2, Dost Ongur2
1McLean Hospital/Harvard Medical School, 115 Mill St., Belmont, MA, 02478, USA. klewandowski@mclean.harvard.edu.
Trials
|March 13, 2016
Summary
This study introduces an internet-based cognitive remediation program for bipolar disorder with psychosis, showing feasibility and potential for improving cognitive function in this population.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Psychology
Background:
- Cognitive dysfunction significantly impacts bipolar disorder with psychosis and functional outcomes.
- Neuroscience-based cognitive remediation shows promise for schizophrenia but is understudied in bipolar disorder.
- Bipolar disorder shares neurocognitive deficits with schizophrenia, necessitating targeted interventions.
Purpose of the Study:
- To evaluate an Internet-based cognitive remediation program for bipolar disorder I with psychosis.
- To develop and validate a dose-matched active control for comparison.
- To assess the durability of cognitive improvements and associated neuroimaging changes.
Main Methods:
- A randomized, blinded clinical trial involving 100 participants with bipolar disorder I and psychosis.
- 24-week intervention with 70 sessions of computer-based activities (treatment vs. control).
- Comprehensive neuropsychological, clinical, and neuroimaging assessments at multiple time points.
Main Results:
- The study successfully implemented and tested an internet-based cognitive remediation program.
- A comparable web-based control paradigm was developed, allowing for blinded assessment.
- Participant blinding was found to be feasible based on user feedback.
Conclusions:
- This is the first study to offer an internet-based cognitive remediation program for bipolar disorder with psychosis.
- The mixed online and in-person format enhances treatment accessibility.
- Findings support the feasibility and potential efficacy of this novel approach.
Related Concept Videos
01:24Mania and Antimanic Drugs: Overview
756
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
756
01:26Psychosis: Goals of Pharmacotherapy
660
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
660
01:25Cognitive Therapy
1.4K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.4K
01:24Rational Emotive Behavior Therapy
631
Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
631
01:28Psychosis and Antipsychotic Drugs: Overview
1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
01:28Drug Therapy
391
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
391