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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
[Pathophysiology of eosinophilic granulomatosis with polyangitis (Churg-Strauss)]
B Chaigne1, J Dion1, L Guillevin2
1Inserm, U1016, institut Cochin, Paris, France; CNRS, UMR8104, Paris, France; Faculté de médecine, université Paris Descartes, département de médecine interne, centre de référence pour les vascularites nécrosantes et la sclérodermie systémique, hôpital Cochin, Assistance publique-Hôpitaux de Paris, Paris, France.
Abstract:
Eosinophilic granulomatosis with polyangitis (EGPA) (formerly Churg-Strauss syndrome) is a rare small-sized vessel vasculitis belonging to the group of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides. MPO-ANCA is present in only 31 to 38% of patients. In this review, we describe the pathophysiology of EGPA, which is characterized by a genetic predisposition, an environmental association, and a cellular dysfunction of eosinophils, neutrophils, and T and B cells.
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