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Related Experiment Video

Updated: Mar 24, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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High-resolution intracranial vessel wall imaging using 3D CUBE T1 weighted sequence.

Ming-Li Li¹, Yu-Yuan Xu², Bo Hou¹

¹Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

European Journal of Radiology

|March 15, 2016

Summary

High-resolution 3D CUBE T1WI is a feasible technique for intracranial vessel wall imaging, clearly displaying vessel walls and lumen. This method accurately detects intracranial artery abnormalities with high reproducibility.

Keywords:

High-resolution Intracranial artery Magnetic resonance imaging T1 weighted imaging Three-dimensional imaging Vessel wall imaging

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Area of Science:

Radiology
Medical Imaging
Neuroimaging

Background:

Intracranial vessel wall imaging is crucial for diagnosing cerebrovascular diseases.
High-resolution imaging techniques are needed to visualize subtle vessel wall pathologies.

Purpose of the Study:

To assess the feasibility of using high-resolution 3D CUBE T1-weighted imaging (T1WI) for intracranial vessel wall imaging.
To evaluate the image quality and reproducibility of this technique in depicting intracranial arteries.

Main Methods:

Retrospective evaluation of high-resolution 3D CUBE T1WI (0.4 mm resolution) in 50 patients.
Scoring of vessel wall and lumen visualization using a 5-point scale.
Calculation of inter-observer and intra-observer reproducibility for identifying plaques, hemorrhage, thrombosis, and enhancement.

Main Results:

A total of 893 artery segments were analyzed, demonstrating clear visualization of vessel walls and lumens.
Image quality scores varied by segment, with highest scores for C6-7 segments and lowest for internal carotid artery C3 segments.
High reproducibility was observed for identifying normal walls, plaques, luminal thrombosis, and wall enhancement.

Conclusions:

High-resolution 3D CUBE T1WI provides clear visualization of intracranial vessel walls and lumens.
The technique effectively detects intracranial artery abnormalities with high diagnostic reproducibility.