Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

36.9K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.9K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.6K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.6K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.9K
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

2.8K
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
2.8K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

710
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
710
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

469
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
469

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addison's disease in Italy: mortality and survival by etiology.

Journal of endocrinological investigation·2026
Same author

Progesterone and IL-6 Expression Are Modulated by Follicular Fluid in Granulosa Cell Cultures.

Biomolecules·2025
Same author

Postural test to differentiate primary aldosteronism from low-renin hypertension: a retrospective single-center study.

Journal of endocrinological investigation·2025
Same author

Beyond Earth, Beyond Time: Preserving Female Fertility in Space Missions.

Journal of clinical medicine·2025
Same author

An Intriguing Case Report of Type 2 Autoimmune Polyendocrine Syndrome Post-SARS-CoV-2: Cause or Coincidence?

Endocrine, metabolic & immune disorders drug targets·2025
Same author

Adrenal crisis: incidence, clinical presentation and risk factors in patients with Addison's disease.

Endocrine·2025

Related Experiment Video

Updated: Mar 24, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.5K

Hyperaldosteronism: Screening and Diagnostic Tests.

Chiara Sabbadin1, Francesco Fallo2

  • 1Endocrinology, Department of Medicine-DIMED, University of Padova, Padua, Italy.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|March 15, 2016
PubMed
Summary

Primary aldosteronism (PA), a common cause of hypertension, requires wider screening. Early detection through aldosterone-to-renin ratio (ARR) testing and confirmatory tests improves patient outcomes.

Keywords:
AldosteroneHypertensionPrimary aldosteronism

More Related Videos

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

10.2K
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

21.0K

Related Experiment Videos

Last Updated: Mar 24, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.5K
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

10.2K
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

21.0K

Area of Science:

  • Endocrinology
  • Cardiology
  • Nephrology

Background:

  • Primary aldosteronism (PA) is the most frequent secondary cause of hypertension, affecting 10% of hypertensive individuals and 20% of those with drug-resistant hypertension.
  • Excess aldosterone contributes to cardiovascular, renal, and metabolic complications, independent of blood pressure effects.

Purpose of the Study:

  • To emphasize the importance of increased screening for PA.
  • To guide the selection of appropriate diagnostic tests for PA detection.

Main Methods:

  • Recommends screening for PA in high-prevalence patient groups, including those with type 2 diabetes mellitus and obstructive sleep apnea.
  • Highlights the aldosterone-to-renin ratio (ARR) as the primary screening tool.
  • Lists confirmatory tests: oral salt loading, saline infusion, captopril challenge, and fludrocortisone suppression test.

Main Results:

  • Effective screening and confirmatory testing prevent unnecessary lateralization procedures in patients with false-positive ARR results.
  • Accurate diagnosis of PA is crucial for appropriate management.

Conclusions:

  • Wider screening for PA is recommended to identify patients who can benefit from specific management.
  • Distinguishing PA subtypes after confirmation is essential for tailored treatment strategies.