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First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis

Vanessa Espinosa1, Amariliz Rivera2

  • 1Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New JerseyNewark, NJ, USA; Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers-The State University of New JerseyNewark, NJ, USA.

Frontiers in Microbiology
|March 15, 2016
PubMed

Insights

Fungal infections are a growing threat, causing millions of deaths globally. Understanding innate immune cells

Area of Science:

  • Immunology
  • Mycology
  • Infectious Diseases

Background:

  • Mycotic infections are increasingly prevalent and deadly, with rising mortality rates.
  • Immunosuppressive and myeloablative therapies contribute to higher incidences of fungal infections.
  • Invasive fungal infections cause approximately 1.5 million deaths annually, primarily from Cryptococcus, Candida, Aspergillus, and Pneumocystis.

Purpose of the Study:

  • To enhance understanding of host immune system mechanisms in containing fungal infections.
  • To facilitate the development of novel antifungal therapies.
  • To review host-fungi interactions, focusing on innate cell-mediated control of pulmonary aspergillosis.

Main Methods:

  • Review of current scientific literature on host-fungi interactions.
  • Focus on innate immune cell recognition and containment mechanisms.
  • Specific examination of pulmonary aspergillosis models.

Main Results:

  • Innate immune cells are critical for rapid recognition and containment of fungal pathogens.
  • Specific mechanisms of innate cell-mediated defense against fungi are elucidated.
  • Insights into host-pathogen interactions in pulmonary aspergillosis are provided.

Conclusions:

  • A deeper understanding of innate immunity is crucial for combating fungal infections.
  • Targeting innate immune responses may lead to effective new antifungal treatments.
  • Further research into host-fungi interactions, particularly in pulmonary aspergillosis, is warranted.
Keywords:
aspergillosisdendritic cells (DC)innate cellsmechanisms of resistancemonocytes subsetsneutrophils

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