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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long noncoding RNAs in psychiatric disorders.

Lingjun Zuo1, Yunlong Tan, Zhiren Wang

  • 1Departments of aPsychiatry bCellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut cDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee dDepartment of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, Texas eDepartment of Psychology, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Neveda, USA fBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.

Psychiatric Genetics
|March 15, 2016
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Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) regulate biological processes and are implicated in psychiatric disorders. This review covers lncRNA functions, identification, and their potential as diagnostic and therapeutic targets for mental health conditions.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Long noncoding RNAs (lncRNAs) are transcripts over 200 nucleotides with regulatory roles.
  • lncRNAs are increasingly recognized for their fundamental biological process governance.
  • Emerging evidence links lncRNAs to complex biological regulation.

Purpose of the Study:

  • To provide a comprehensive review of long noncoding RNAs (lncRNAs).
  • To explore the definition, distribution, identification, databases, analysis, classification, and functions of lncRNAs.
  • To discuss the role of lncRNAs in psychiatric disorders and their clinical implications.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs.
  • Analysis of current methodologies for lncRNA identification and characterization.
  • Examination of studies investigating lncRNA involvement in psychiatric disease etiology.

Main Results:

  • lncRNAs possess diverse regulatory functions across fundamental biological processes.
  • Established methods exist for lncRNA identification, analysis, and classification.
  • lncRNAs show significant potential in understanding psychiatric disorder development.

Conclusions:

  • lncRNAs are critical regulators with broad biological functions.
  • Further research into lncRNAs can elucidate psychiatric disorder mechanisms.
  • lncRNAs may offer novel avenues for clinical diagnosis and therapeutic strategies in psychiatry.