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Published on: April 24, 2018
Calcium oxalate precipitation by diffusion using laminar microfluidics: toward a biomimetic model of pathological
G Laffite1, C Leroy2, C Bonhomme2
1Sorbonne Universités, UPMC Univ Paris 06, UMR 8234 CNRS, Laboratoire Physico-chimie des Electrolytes et Nanosystèmes Interfaciaux (PHENIX), 4 place Jussieu - case 51, F-75005, Paris, France. ali.abou_hassan@upmc.fr and Sorbonne Universités, UPMC Univ Paris 06, CNRS, Collège de France, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), 11 Place Marcelin Berthelot, Bat D, F-75005, Paris, France.
Abstract:
The effect of mixing calcium and oxalate precursors by diffusion at miscible liquid interfaces on calcium oxalate crystalline phases, and in physiological conditions (concentrations and flow rates), is studied using a microfluidic channel. This channel has similar dimensions as the collection duct in human kidneys and serves as a biomimetic model in order to understand the formation of pathological microcalcifications.
