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Updated: Mar 24, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Dysregulation of ion fluxes in bipolar affective disorder
H C Grunze1, J Langosch2, C Normann2
11Department of Psychiatry,LMU München,Germany.
Abstract:
Bipolar disorder has attracted numerous research from different neurobiological angles. This review will summarize selected findings focusing on the role of disturbed transmem-braneous ion fluxes. Several mood stabilizers exhibit a distinct profile including effects on sodium, calcium and potassium conductance. In summary, some decisive mechanisms of action as calcium antagonism and modulation of potassium currents may play a crucial role in the success of any given mood stabilizer in bipolar disorder.
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