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Typical and atypical antipsychotics in bipolar disorder
1Aarhus University Psychiatric Hospital,Risskov,Denmark.
Acta Neuropsychiatrica
|March 16, 2016
Summary
Atypical antipsychotics are preferred over typical ones for bipolar disorder treatment to minimize side effects, though long-term use requires further study. Both types show benefits in mania management.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Typical antipsychotics are common in bipolar disorder treatment, often as adjuncts.
- Recent focus is on atypical antipsychotics for bipolar disorder.
- This review examines antipsychotic pros and cons in bipolar disorder.
Purpose of the Study:
- To review the advantages and disadvantages of antipsychotics in bipolar disorder treatment.
- To compare typical and atypical antipsychotics for bipolar disorder management.
Main Methods:
- Review of randomized controlled trials (RCTs).
- Inclusion of cited review articles.
Main Results:
- Typical antipsychotics are effective for mania and severe agitation.
- Long-term use of typical antipsychotics may induce depression.
- Atypical antipsychotics like risperidone and olanzapine are effective antimanics; clozapine is useful for refractory cases.
Conclusions:
- Antipsychotics are beneficial for specific manic presentations.
- Atypical agents are preferred over typical ones to reduce side effects, except when parenteral administration is necessary.
- Antipsychotics may aid in treating psychotic bipolar depression, despite limited RCTs.
- Long-term use of typical antipsychotics is restricted; the role of atypical antipsychotics requires further investigation.
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