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Bladder Cancer Chemopreventive Agents: Current Knowledge and Concepts
N Rezakahn Khajeh1, C Khoyilar1, Y Wu1
1Assistant Clinical Professor, Urology Department, University of California, California, Irvine, CA, United States.
Mini Reviews in Medicinal Chemistry
|March 16, 2016
Summary
Preventing bladder cancer with natural or pharmaceutical agents is desirable but controversial. Current evidence is insufficient to link these agents to reduced bladder cancer risk.
Area of Science:
- Oncology
- Urology
- Preventative Medicine
Background:
- Bladder cancer is a prevalent urinary tract malignancy with high morbidity and mortality.
- Reducing the burden of bladder cancer through preventative strategies is a significant medical goal.
- The use of natural and pharmaceutical products for bladder cancer prevention is currently debated.
Purpose of the Study:
- To review the existing evidence on natural dietary substances for bladder cancer chemoprevention.
- To examine the potential chemopreventive roles of pharmaceutical agents in bladder cancer.
- To assess the overall efficacy and controversy surrounding these preventative approaches.
Main Methods:
- Literature review of scientific studies on chemoprevention of bladder cancer.
- Analysis of evidence for natural dietary substances.
- Evaluation of evidence for pharmaceutical agents.
Main Results:
- A review of current literature was conducted.
- Evidence for natural dietary substances and pharmaceutical agents was examined.
- The data did not establish a clear link between proposed agents and bladder cancer risk.
Conclusions:
- The current body of evidence is insufficient to confirm the effectiveness of proposed chemopreventive agents for bladder cancer.
- Further research is needed to establish a definitive link between these agents and bladder cancer risk reduction.
- The controversy surrounding natural and pharmaceutical products for bladder cancer prevention persists due to limited conclusive data.
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