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    Area of Science:

    • Cardiology
    • Psychiatry
    • Psychosomatic Medicine

    Background:

    • Affective disorders frequently co-occur with cardiac diseases, especially coronary artery disease (CAD).
    • Affective dysregulation is a significant risk factor for cardiac mortality in CAD patients.
    • Current treatment algorithms for affective disorders in cardiac patients are lacking evidence-based guidelines.

    Purpose of the Study:

    • To propose an etiological model for the interplay between affective and cardiac dysregulation.
    • To provide a framework for understanding the relationship between stress and cardiac/affective disorders.

    Main Methods:

    • Literature review on affective disorders and cardiac disease.
    • Development of a theoretical etiological model.
    • Application of the stress-diathesis model framework.

    Main Results:

    • The proposed model integrates psychiatric and cardiac perspectives on dysregulation.
    • The stress-diathesis model offers a potential explanation for the co-occurrence of these conditions.
    • Highlights the need for integrated treatment approaches.

    Conclusions:

    • A comprehensive etiological model is needed to address affective disorders in CAD.
    • The stress-diathesis model provides a valuable framework for research and clinical practice.
    • Further research is warranted to develop evidence-based treatment strategies.