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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

345
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
345
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

799
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
799
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

330
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
330
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

311
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
311
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

561
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
561
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

314
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
314

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Related Experiment Video

Updated: Mar 24, 2026

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

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An 81 Year Old with Back Pain.

Sukhpreet S Dubb1, Joanna M Farrant2, B V Praveen3

  • 1Broomfield Hospital, Essex.

Annals of Medicine and Surgery (2012)
|March 16, 2016
PubMed
Summary
This summary is machine-generated.

An 81-year-old male presented with acute abdominal and back pain, classic symptoms of a ruptured abdominal aortic aneurysm. Immediate CT scan confirmed the diagnosis, enabling urgent surgical intervention for this life-threatening condition.

Keywords:
Acute abdomenAneurysmCT scanShock

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Area of Science:

  • Vascular surgery
  • Emergency medicine
  • Diagnostic imaging

Background:

  • Abdominal aortic aneurysms (AAAs) are a significant cause of mortality, particularly in elderly male smokers.
  • Rupture of an AAA presents as a surgical emergency with high mortality rates.
  • Risk factors include advanced age, male sex, and a history of smoking.

Purpose of the Study:

  • To highlight the critical importance of prompt diagnosis and management of suspected abdominal aortic aneurysm rupture in the emergency setting.
  • To emphasize the role of clinical suspicion and imaging in identifying this life-threatening condition.

Main Methods:

  • Clinical presentation of an 81-year-old male with severe abdominal and back pain.
  • Physical examination revealing abdominal tenderness and a pulsatile mass.
  • Diagnostic imaging utilizing computed tomography (CT) scan of the abdomen.

Main Results:

  • The patient exhibited symptoms consistent with a ruptured abdominal aortic aneurysm.
  • Physical findings, including a pulsatile abdominal mass, raised immediate suspicion.
  • CT scan confirmed the diagnosis of abdominal aortic aneurysm rupture.

Conclusions:

  • Prompt recognition of clinical signs and symptoms is crucial for the timely diagnosis of ruptured abdominal aortic aneurysms.
  • CT imaging is essential for confirming the diagnosis and guiding urgent surgical management.
  • Early intervention in cases of suspected AAA rupture significantly impacts patient outcomes.