Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Agreement between ganglion cell-inner plexiform layer metrics from widefield optical coherence tomography and Goldmann II, III, and V in glaucoma.

Optometry and vision science : official publication of the American Academy of Optometry·2026

Same author

Repeatability of choroidal optical coherence tomography angiography metrics in healthy young adults.

Clinical & experimental optometry·2026

Same author

Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.

Investigative ophthalmology & visual science·2026

Same author

Genome-wide discovery reveals 30 loci for choroidal thickness and uncovers potential causal links with angle-closure glaucoma.

medRxiv : the preprint server for health sciences·2026

Same author

Computational aberration correction enables full-thickness retinal imaging with adaptive optics optical coherence tomography.

Biocybernetics and biomedical engineering·2026

Same author

Spatio-temporal optical coherence imaging and tomography for <i>in vivo</i> applications.

Journal of biomedical optics·2026

Same journal

Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.

Biomedical optics express·2026

Same journal

Erratum: Review of dynamic optical coherence tomography for intracellular motility [Invited]: errata.

Biomedical optics express·2026

Same journal

Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy.

Biomedical optics express·2026

Same journal

Synergistic combination of convective self-assembly and hollow core fiber for sensitive SERS detection of glucose molecules.

Biomedical optics express·2026

Same journal

Multimodal diagnostic network integrating infrared and mass spectra for lung cancer.

Biomedical optics express·2026

Same journal

Multimodal Optical Biosensing for Precision Medicine and Healthcare: Introduction to the feature issue.

Biomedical optics express·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 24, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Tissue thickness calculation in ocular optical coherence tomography.

David Alonso-Caneiro¹, Scott A Read¹, Stephen J Vincent¹

¹Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Biomedical Optics Express

|March 16, 2016

Summary

This summary is machine-generated.

Optical coherence tomography (OCT) eye imaging thickness measurements can be inaccurate due to image tilt and curvature. Alternative thickness metrics should be considered to improve accuracy in ocular research and clinical diagnosis.

Keywords:

(100.0100) Image processing (100.2960) Image analysis (110.4500) Optical coherence tomography (170.4470) Ophthalmology

More Related Videos

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

Related Experiment Videos

Last Updated: Mar 24, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography (OCT) is crucial for eye imaging, providing anatomical and physiological data.
Thickness measurements from OCT are vital for diagnosing and monitoring ocular conditions.
Current axial thickness metrics may be biased by image tilt and posterior eye curvature.

Purpose of the Study:

To compare standard axial thickness calculations with alternative metrics for estimating ocular tissue thickness.
To evaluate the impact of image tilt and posterior segment curvature on thickness measurements.
To identify more accurate methods for OCT-derived thickness estimation.

Main Methods:

Tested standard axial thickness calculations against alternative metrics.
Utilized wide-field chorio-retinal OCT scans (60° x 25° FOV).
Systematically examined the effects of image tilt and posterior eye curvature.

Main Results:

Image tilt and posterior segment curvature significantly affect axial thickness calculations.
Alternative thickness metrics demonstrated reduced bias from tilt and curvature.
The study highlighted potential measurement errors with standard axial methods.

Conclusions:

Axial thickness calculations in OCT imaging can be prone to errors.
Alternative metrics offer a more reliable approach to estimating ocular tissue thickness.
Considering alternative methods is essential to avoid measurement inaccuracies in OCT analysis.