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Updated: Mar 24, 2026

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
Published on: October 13, 2016
[Cognitive impairment in amyotrophic lateral sclerosis]
G N Levitsky1, V M Gilod2, R V Chub3
1Russian Charity ALS Foundation, Moscow; 'Real Health Clinic', Moscow; Medical Preventive Ambulatory #51, Moscow.
Cognitive changes are common in amyotrophic lateral sclerosis (ALS) patients, affecting over a third and correlating with faster disease progression. However, these changes do not impact emotional state or quality of life.
Area of Science:
- Neurology
- Neuroscience
- Cognitive Science
Context:
- Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
- Cognitive and emotional impairments are increasingly recognized in ALS patients.
- Understanding these changes is crucial for comprehensive patient care.
Purpose:
- To assess the prevalence and nature of cognitive and emotional status in ALS patients.
- To investigate the relationship between cognitive changes and disease progression.
- To determine the impact of cognitive changes on emotional well-being and quality of life.
Summary:
- 35.3% of ALS patients exhibited frontotemporal cognitive changes (CC), with 4.2% having dementia.
- Cognitive changes were associated with older age and more rapid ALS progression.
- No significant influence of cognitive changes on emotional state or quality of life was observed.
Impact:
- Highlights the high prevalence of cognitive impairment in ALS.
- Suggests cognitive status as a potential prognostic factor in ALS progression.
- Informs clinical management by indicating that emotional well-being may be preserved despite cognitive deficits.
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