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Updated: Mar 24, 2026
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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
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[Intercurrent and autoimmune processes in type 1 diabetes mellitus]
O S Derevyanko1, T V Nikonova1, O M Smirnova1
1Endocrinology Research Centre, Ministry of Health of Russia, Moscow, Russia.
Terapevticheskii Arkhiv
|March 16, 2016
Summary
Patients with type 1 diabetes mellitus (DM1) often have markers for other autoimmune diseases, even without symptoms. This suggests a higher risk of co-occurring conditions in individuals with DM1.
Area of Science:
- Endocrinology
- Immunology
- Hepatology
Context:
- Type 1 diabetes mellitus (DM1) is an autoimmune condition.
- Co-occurring autoimmune diseases are common in DM1 patients.
- Autoantibodies are key indicators of autoimmune diseases.
Purpose:
- To determine the prevalence of autoantibodies linked to connective tissue and liver autoimmune diseases in DM1 patients.
- To analyze the clinical characteristics of DM1 patients who test positive for these autoantibodies.
Summary:
- A study of 84 patients with DM1 revealed a high prevalence of autoantibodies associated with connective tissue and liver autoimmune diseases.
- These autoantibodies were detected even in DM1 patients lacking clinical symptoms or instrumental signs of these conditions.
- The findings indicate a significant overlap between DM1 and other autoimmune disorders.
Impact:
- Suggests an increased risk of concomitant autoimmune diseases in individuals with type 1 diabetes mellitus.
- Highlights the potential for asymptomatic autoimmune conditions in DM1 patients.
- Emphasizes the importance of screening for other autoimmune diseases in DM1 management.
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